Building on previous findings, we aim to systematically map the spatiotemporal dynamics of myelin turnover and neuroglial networks. Our goal is to uncover the root causes of brain myelinopathy and translate these insights into diagnostic and therapeutic advancements.
To achieve this, we will investigate the molecular and cellular architecture of brain regions, with a particular emphasis on white matter (WM) integrity. At the core of our approach is the concept of the microenvironment, recognizing that no cell operates in isolation within the brain.
Within this framework, we will focus on the following key areas:
How can we establish a comprehensive framework for evaluating WM health? Additionally, how can we design strategies to effectively monitor and reverse its decline?
What endogenous mechanisms suppress the expansion of WM lesions, and under what conditions does this regulatory control become disrupted?
What are the primary triggers of lesion formation? Do disruptions in the brain’s border integrity and fluid exchange processes inevitably trigger the onset of demyelination?
Glial-vascular-immune secretory networks form distinctive microenvironments at the brain barriers in marmosets during neuroinflammation
Citation: Lin JP*, Brake A, Donadieu M, Lee A, Smith G, Hu K, Nair G, Kawaguchi R, Sati P, Geschwind DH, Jacobson S, Schafer DP, Reich DS*. Science 2025 Feb
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Glia exhibit regional heterogeneity in density, morphology, molecular complexity, and interconnectivity within marmoset brains
Citation: Lin JP, Kelly HM, Song Y, Kawaguchi R, Geschwind DH, Jacobson S, Reich DS. Nat Commun 2022 Sep
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LRP1 enhances myelinogenesis via cholesterol and peroxisome biogenesis pathways
Citation: Lin JP, Mironova YA, Shrager P, Giger RJ. eLife 2017 Dec
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